Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1095 | Female Reproduction | ECE2017

Administration of first line anti-tuberculosis drugs induces ovarian and uterine oxidative stress and disruption of endocrine balance in rats

Adaramoye Oluwatosin , Adebayo Olayinka , Adesanoye Omolola , Abolaji Amos , Kehinde Aderemi

The first line anti-tuberculosis (anti-TB) drugs; isoniazid (INH), rifampicin (RIF), ethambutol (EMB) and pyrazinamide (PZA) were effective in the treatment of pulmonary tuberculosis. However, the toxicity of these drugs has been of great concern in clinical settings. This study was designed to evaluate the toxic effects of anti-TB drugs on reproductive system in female rats. Thirty-five female Wistar rats were assigned into five groups of seven animals each. The control recei...